Pete Ploszek

Leonardo

Alan Ritchson

Raphael

Jeremy Howard

Donatello

Noel Fisher

Michelangelo

Megan Fox

April O'Neil

Will Arnett

Vern Fenwick

William Fichtner

Eric Sacks

Danny Woodburn

Splinter

Johnny Knoxville

Leonardo (voice)

Tony Shalhoub

Splinter (voice)

Tohoru Masamune

Shredder

Whoopi Goldberg

Bernadette Thompson

Minae Noji

Karai

Abby Elliott

Taylor

Madison Mason

Councilman

Taran Killam

McNaughton

K. Todd Freeman

Dr. Baxter Stockman

Paul Fitzgerald

Dr. O'Neil

Malina Weissman

Young April O'Neil

Venida Evans

Subway Hostage

Mikal Vega

Sacks Bodyguard

Harley Pasternak

Harley Pasternak

Braeson Herold

Reporter

Chris Wylde

Reporter

Chance Kelly

Mr. Rivetti

Rick Chambers

News Anchor

Leyna Nguyen

News Anchor

Derek Mears

Dojo Ninja